This review describes the use of Magnetofection for in vivo appliations in cancer field and highlights the interest of in vivo PolyMag, in vivo DogtorMag and in vivo ViroMag for in vivo cell transfection.
Magnetic nanoparticles: a novel platform for cancer theranostics.
Abstract
Multifunctional nanoplatforms
represent a cutting edge tool in biomedical applications as a result of
their applicability in the concurrent monitoring of medical treatment. Magnetic nanoparticles (MNPs) have generated great interest in the field of cancer nanotheranostics owing to their intrinsic magnetic property that enables them to be used as contrast agents in magnetic
resonance imaging and as a therapeutic system in conjunction with
hyperthermia. In addition, the physical properties and biocompatibility
of MNPs help them to act as efficient drug carriers for targeted
therapeutic regimes. In this review, we have discussed the different
theranostic applications of MNPs. Further, we have raised the current
challenges associated with the clinical translation of MNPs along with
future opportunities in this field.
In vivo MagnetoFection™ has been developed for in vivo targeted transfection of various types of nucleic acids such as DNA, RNA, oligonucleotides or transduction with any viral vectors.
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